PolysacDB 35 and 50 KDa surface glycoconjugates 2489

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

35 and 50 KDa surface glycoconjugates

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Trypanosoma cruzi strain G

[edit] Basic Structure

N/A

[edit] Proposed functions

These glycoconjugates may play an important role in the metacyclic form-host cell association that initiates T. cruzi infection

[edit] Antigenic Nature used to produce antibodies

Killed strain G metacyclic forms

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 10D8

[edit] Antibody type and class

N/A

[edit] Assay System

ELISA, immunoblotiing, parasite invasion assay

[edit] Cross-reactivity

10D8 was found to react with metacyclic trypomastigotes from triatomine or from culture as well as with epimastigotes but not with tissue amastigotes or blood trypomastigotes

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

The invasion of Vero cells by metacyclic forms of strains Tulahuen and G was inhibited 50 to 67% in the presence of 10D8. Mice that had passively received 10D8 before challenge with metacyclic forms, a considerable decrease in the parasitemia levels was observed

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database