Salmonella typhi
From DrugPedia: A Wikipedia for Drug discovery
Salmonella typhi
It is a Gram negative, obligate parasite that has no known natural reservoir outside of humans. It is also able to inhibit the oxidative burst of leukocytes, making innate immune response ineffective. It is adapted to humans and does not occur in animals.
| Kingdom | Bacteria |
|---|---|
| Class | Gamma Proteobacteria |
| Order | Enterobacteriales |
| Family | Enterobacteriaceae |
| Genus | Salmonella |
| Species | S. typhi |
| Binomial | Salmonella typhi |
Contents |
[edit] Surface Characteristics
The salmonella Vi Capsular polysaccharide is a linear homopolymer of α[1-->4]-O-acetyl-N-acetyl-galactosaminuronic acid. LPS O-antigens are formed by the polymerization of a tetrasaccharide repeating unit which is composed of [tyvelose-α[1-->3]-D-mannose-α[1-->3]-L-rhamnose-α[1-->3]-Dα[1-->2]
[edit] Transmission
The infection usually occurs as a result of massive ingestion of foods in which the bacteria are highly concentrated. The contamination could be through inhalation of bacteria-laden dust. In addition transmission to humans takes place through: excretions from either sick or infected but apparently clinically healthy people and animals, polluted surface water and standing water, unhygienically thawed fowl, an association with reptiles etc.
[edit] Pathogenic Activity
The germ multiplies in the intestinal lumen causing an intestinal inflammation with diarrhea that is often muco-purulent and bloody. In infants, dehydration can cause a state of severe toxicosis. They also cause illnesses such as typhoid fever, paratyphoid fever, and the foodborne illness salmonellosis.
