Nuclear receptor DAX-1;
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Contents |
Source Organism
Callithrix jacchus (Common marmoset).
Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Platyrrhini; Cebidae; Callitrichinae; Callithrix.
Subcellular Localization
Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity).
Developmental Stage
Similarity
Belongs to the nuclear hormone receptor family. NR0 subfamily.
Post translational Modification
Function
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
