Nuclear receptor subfamily 1 group B member 1-B
From DrugPedia: A Wikipedia for Drug discovery
Contents |
Source Organism
Danio rerio (Zebrafish) (Brachydanio rerio).
Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;Cyprinidae; Danio.
Subcellular Localization
Nucleus.
Developmental Stage
Expressed both maternally and zygotically. At 9 hours post-fertilization (hpf), expressed in the dorsal epiblast and prospective tail regions, but absent from the ventral epiblast. At 10 hpf, expressed in presumptive diencephalon and hindbrain, in tissue lateral to the head, the posterior neural plate, tail bud and adjacent mesoderm. During somitogenesis, head and tail expression remains. At 24 hpf, low levels of ubiquitous expression with stronger expression in eyes, hindbrain and spinal cord; in hindbrain the anterior border is at rhombomeres 3-4. Also expressed in non-neural tissues including pharyngeal endoderm, mesenchyme and tail bud. At 48 hpf, expression is maintained in hindbrain, eyes, diencephalon and the pharyngeal region, and is also observed in forebrain, midbrain and pectoral fin bud.
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post translational Modification
Function
This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.
