Antidiuretic factor A
From DrugPedia: A Wikipedia for Drug discovery
Contents |
Description
Antidiuretic factor A (ADFa) (ADF) (Antidiuretic hormone A) (ADHA).
Source Organism
Tenebrio molitor (Yellow mealworm).
Taxomomy
Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;Tenebrionidae; Tenebrio.
Subcellular Localization
Secreted.
Developmental Stage
Similarity
To T.molitor cuticular protein LPCP29 C-terminal region.
Post translational Modification
Function
Strong inhibitor of fluid secretion by the Malpighian tubules. Uses cGMP as a second messenger and inhibits fluid production by decreasing cAMP concentration. Reduces isosmotic fluid secretion by inhibiting electroneutral and non-conductive transport pathways. Reverses the stimulatory effect of diuretic hormone I
