PolysacDB 35 and 50 KDa surface glycoconjugates 2489
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
35 and 50 KDa surface glycoconjugates
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Trypanosoma cruzi strain G
[edit] Basic Structure
N/A
[edit] Proposed functions
These glycoconjugates may play an important role in the metacyclic form-host cell association that initiates T. cruzi infection
[edit] Antigenic Nature used to produce antibodies
Killed strain G metacyclic forms
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 10D8
[edit] Antibody type and class
N/A
[edit] Assay System
ELISA, immunoblotiing, parasite invasion assay
[edit] Cross-reactivity
10D8 was found to react with metacyclic trypomastigotes from triatomine or from culture as well as with epimastigotes but not with tissue amastigotes or blood trypomastigotes
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
The invasion of Vero cells by metacyclic forms of strains Tulahuen and G was inhibited 50 to 67% in the presence of 10D8. Mice that had passively received 10D8 before challenge with metacyclic forms, a considerable decrease in the parasitemia levels was observed
