PolysacDB Lipoarabinomannan 1007

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipoarabinomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Mycobacterium tuberculosis

[edit] Basic Structure

Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor

[edit] Proposed functions

T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages

[edit] Antigenic Nature used to produce antibodies

Heat killed Mycobacterium tuberculosis

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 5c11

[edit] Antibody type and class

IgM

[edit] Assay System

Indirect immunofluorescence, ELISA, western blotting

[edit] Cross-reactivity

This antibody cross-reacted with large number of mycobacterial species.

[edit] Proposed epitopes

Arabinose moiety of Lipoarabinomannan

[edit] Proposed Utility

This antibody has been used in the detection of mycobacteria in clinical samples

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database