AntiBP

From DrugPedia: A Wikipedia for Drug discovery

AntiBP is a bioinformatics based server that discriminates the antibacterial peptides from non-antibacterial peptides. Prediction are done by using QM,ANN and SVM based methods using binary patterns of peptide sequences. The overall accuracy of this server is ~92.11%.This server can be useful for designing the peptide based antibiotics. This server is freely accessible at http://www.imtech.res.in/raghava/antibp .

The server accepts a peptide sequence either in simple single letter amino acid or any standard format. The server requires the user to define the format of the input sequence i.e. whether the sequence is in plain text or FASTA/PIR/EMBL/GENBANK etc. format. The server uses ReadSeq to inter-convert the format of the peptide sequences. Multiple sequences may be submitted at one time. Antibp predicts the antibacterial peptides of length 15 residues only. So if you provide a peptide longer in length, your peptide would be chopped into overlapping peptides of length 15 and predictions would be done for the resulting peptides. For bug reports please contact at: [email protected]

The result is displayed in a tabular format. The table displayed has 4 columns with the peptide sequence in the first column, position of the peptide in second column (in case the query peptide is longer than 15 residues and is chopped for predictions), prediction score in third column and the antibacterial activity in the last column. The server also maps known antibacterial peptides on query sequence.

AntiBP is a novel method developed at Dr. G.P.S. Raghava's group. This method can predict whether a peptide is antibacterial or not with high accuracy. AntiBP (Antibacterial peptides) is developed in order to discover efficacious antibacterial peptides, which will prove to be a boon to combat the dreadful antibiotic resistant bacteria.