CarboDB Core oligosaccharide 2035
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Core oligosaccharide
[edit] Carbohydrate Class
Core oligosaccharide [LPS]
[edit] Source Microbe
Pseudomonas aeruginosa
[edit] Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Formalin killed whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab KN-2B11
[edit] Antibody type and class
IgM
[edit] Assay System
competitive enzyme immunoassay, ELISA, immunoblotting
[edit] Cross-reactivity
"This MAb specifically bound to clinical isolates belonging to Homma serotypes A, F, G and K at a frequency of 70 to 86% and to serotypes H and M isolates at about 50%. They did not bind to any isolates of serotype B, E, and I tested."
[edit] Proposed epitopes
α-L-rhamnose residues in the outer core of LPS might be the part of the epitope.
[edit] Proposed Utility
This Mab agglutinated P. aeruginosa cells
