CarboDB Lipoarabinomannan-B 1631
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoarabinomannan-B
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium leprae
[edit] Basic Structure
Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
[edit] Proposed functions
T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
[edit] Antigenic Nature used to produce antibodies
soluble extract of M. leprae
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab SAl.C7F
[edit] Antibody type and class
IgG1
[edit] Assay System
Antigen capture ELISA, direct binding assay,
[edit] Cross-reactivity
This Mab was specific to M. leprae and did not cross-react with lipoarabinomannan from M. tuberculosis
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab becomes applicable for monitoring several individual M . Leprae antigens such as lipoarabinomannan
