CarboDB Lipoarabinomannan 1011
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoarabinomannan
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium tuberculosis
[edit] Basic Structure
Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
[edit] Proposed functions
Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
[edit] Antigenic Nature used to produce antibodies
Heat killed Mycobacterium tuberculosis
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab lam701
[edit] Antibody type and class
IgG3
[edit] Assay System
Sandwich ELISA
[edit] Cross-reactivity
This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
[edit] Proposed epitopes
N\A
[edit] Proposed Utility
These antibodies could be used to detect mycobacterial antigens in sputum
