Cepharanthine
From DrugPedia: A Wikipedia for Drug discovery
| Cepharanthine
| |
| Systematic (IUPAC) name | |
| N/A | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C37H38N2O6 |
| Mol. mass | 606.70742 |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
[edit] Description
isoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system afte administration of antineoplastic agents or x-irradiation; structure
Cepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata. It has anti-inflammatory, anti-allergic, immunomodulatory, and many other interesting biological activities. Suppresses NO production, which is one of the critical mediators of inflammation. Inhibits either alone or in combination with 8-difluoromethoxy-1ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyphenyl-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid HIV-1 replication in TNF-a and PMA-stimulated U1 cells. Inhibits in a two-stage carcinogenesis model tumor promotion by TPA. Inhibits both ODC and PKC enzymes involved in the promotional phase of carcinogenesis. Inducer of apoptosis in murine P388 doxorubicin-sensitive and -resistant cells, by increasing the production of reactive oxygen species and Fas-antigen expression. When given in combination with other cancer therapeutic drug such as doxorubicin (Prod. No. LKT-D5794), tamoxifen (Prod. No. LKT-T0250, vindesine (Prod. No. LKT-V3354), vincristine (Prod. No. LKT-V5254), nitrosourea and others, cepharanthine potentiates their therapeutic effects by modulating the multidrug resistance. Similar to minoxidil, it is able to stimulate proliferation and delay initiation of differentiation and keratinization of cultured cells.
[edit] General Properties
*Molecular Weight
606.70742
*Molecular Formula
C37H38N2O6
*IUPAC NAME
N/A
*Canonical Smiles
CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
*Isomeric Smiles
CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
*XLogP
5.7
*Topological Polar Surface Area
61.9
