Dopamine
From DrugPedia: A Wikipedia for Drug discovery
Dopamine Pubchem(681)
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Therapeutic Indications
- Hypotension
- Parkinson Disease
Therapeutic Uses
- cns agent
- cardiovascular agent
KEGG Pathway(C03758,D07870)
- Tyrosine metabolism
- Indole and ipecac alkaloid biosynthesis
- Alkaloid biosynthesis I
- Neuroactive ligand-receptor interaction
- Gap junction
- Parkinson's disease
Activity Antihypotensive,Cardiac stimulant, cardiotonic
| MMDB ID | PDB ID | Reference |
|---|---|---|
| 34790 | 2A3R | Lu JH, Li HT, Liu MC, Zhang JP, Li M, An XM, Chang WRCrystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphateBiochem. Biophys. Res. Commun. v335, p.417-423 |
| 58509 | 5PAH | Erlandsen H, Flatmark T, Stevens RC, Hough ECrystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolutionBiochemistry v37, p.15638-15646 |
| 65041 | 2QMZ | Fu Y, Buryanovskyy L, Zhang Z, 2007/7/17 |
| 65825 | 2VQ5 | Ilari A, Franceschini S, Bonamore A, Boffi A, 2008/3/11 |
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 128 | deg C | EXP | |
| pKa Dissociation Constant | 8.93 | (none) | EXP | |
| log P (octanol-water) | 0.98 | (none) | EXP | |
| Water Solubility | 1.00E+06 | mg/L | 25 | EST |
| Vapor Pressure | 2.57E-05 | mm Hg | 25 | EST |
| Henry's Law Constant | 8.79E-15 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 9.01E-11 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mammal (species unspecified) | LD50 | unreported | 1120mg/kg (1120mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 42, 1990. | |
| mouse | LD50 | intracervical | 74mg/kg (74mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku College of Pharmacy. Vol. 27, Pg. 131, 1980. |
| mouse | LD50 | intraperitoneal | 950mg/kg (950mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: HEMORRHAGE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974. |
| mouse | LD50 | intravenous | 59mg/kg (59mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: HEMORRHAGE | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974. |
| rat | LD50 | intraperitoneal | 163mg/kg (163mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Toxicology and Applied Pharmacology. Vol. 88, Pg. 433, 1987. |
