Flumethasone

From DrugPedia: A Wikipedia for Drug discovery

Show 3-D Structure

Flumethasone
Systematic (IUPAC) name
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number	2135-17-3
ATC code	?
PubChem	16490
Chemical data
Formula	C22H28F2O5
Mol. mass	410.452 g/mol
Synonyms	(6S,8S,9S,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic, CYP3A4-mediated
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Topical

Flumetasone (usually as the pivalic acid ester flumetasone pivalate, trade name Locacorten or Locorten) is a corticosteroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.

An anti-inflammatory glucocorticoid used in veterinary practice.

[edit] General Properties

*Molecular Weight

410.45

*Molecular Formula

C₂₂H₂₈F₂O₅

*IUPAC NAME

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F

*Isomeric Smiles

C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F

[edit] PhysioChemical Properties

*Melting Point

*LogP

1.94(EXP)

*Water Solubility

1(EXP) at 20C

[edit] External Links

• [1]Pubchem
• [2]KEGG Compound
• [3]KEGG Drug