PolysacDB 1798
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
N-propionylated α(2-->8)-linked sialooligosaccharides
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Neisseria meningitidis
[edit] Basic Structure
N-propionylated α(2-->8)-linked sialooligosaccharides
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Tetanus toxoid
[edit] Conjugation Method
The oligosaccharide was activated using NaIO4 at 4C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37C for 5 days
[edit] Antibodies
Mab 7C11
[edit] Antibody type and class
IgG1
[edit] Assay System
ELISA, bactericidal assays
[edit] Cross-reactivity
N/A
[edit] Proposed epitopes
The epitope was located on short internal fragments of the polysaccharide
[edit] Proposed Utility
This Mab would help in the elucidation of the capsular polysaccharide structure
