PolysacDB Capsular Vi polysaccharide 2214
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular Vi polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Salmonella typhi
[edit] Basic Structure
The salmonella Vi Capsular polysaccharide is a linear homopolymer of α[1-->4]-O-acetyl-N-acetyl-galactosaminuronic acid
[edit] Proposed functions
It is an important virulence factor. The Vi capsule shields the bacteria against phagocytosis by its surface negative charge properties and by covering cell-envelope components sensitive to serum opsonins
[edit] Antigenic Nature used to produce antibodies
Heat killed bacteria and purified Vi polysaccharide
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MATy-V5
[edit] Antibody type and class
IgM
[edit] Assay System
inhibition enzyme immunoassay
[edit] Cross-reactivity
This Mab was specific to Vi antigen
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab was shown to be a useful serotyping agent by correct identification in slide agglutination tests of 32 clinical isolates of all the S. typhi and other serogroup D salmonellae among a total of 140 bacterial isolates representing eight different Enterobacteriaceae genera tested
