PolysacDB Capsular polysaccharide 2423
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Streptococcus Group B
[edit] Basic Structure
The structure of type III polysaccharide is as follows : -3-β-D-Galp-(1-->4)-β-D-Glcp-(1-->6)-β-D-GlcNAcp-(1--> along with the fact that the carboxyl of the -D-NeuNAcp was linked to the O-3 of the adjacent D-galactose to form the type-specific site
[edit] Proposed functions
The property of invasiveness is related to the anti-phagocytic properties conferred to Group B Streptococcus by its capsular polysaccharide
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab GBS II/4-1OBA9
[edit] Antibody type and class
N/A
[edit] Assay System
Counterimmunoelectrophoresis, Radioactive binding assay, Ouchterlony double-diffusion, Latex particle agglutination tests
[edit] Cross-reactivity
A9 antibody cross-reacted with group B antigen in gel diffusion reactions with extracts of Lancefield group A, B, C, D, F, and G streptococci
[edit] Proposed epitopes
Rhamnose is not an immunodominant determinant contrasts with polyclonal rabbit antiserum to this antigen
[edit] Proposed Utility
This Mab was a highly sensitive reagent in detecting soluble group B antigen by counterimmunoelectrophoresis. A9 antibody-coated latex particles were compared with a commercially available polyclonal latex agglutination reagent and shown to be equally sensitive and specific in the detection of soluble group B antigen in urine and cerebrospinal fluid from patients with GBS infections
