PolysacDB Lipoarabinomannan 1010

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Contents

[edit] Carbohydrate Name

Lipoarabinomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Mycobacterium tuberculosis

[edit] Basic Structure

Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor


[edit] Proposed functions

Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade

[edit] Antigenic Nature used to produce antibodies

Heat killed Mycobacterium tuberculosis

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

SMITB14

[edit] Antibody type and class

IgG1

[edit] Assay System

N\A

[edit] Cross-reactivity

SMITB14 bound to whole M. tuberculosis bacteria (H37Rv and Harlingen strains) as well as to the attenuated BCG, but not to other species such as Escherichia coli strains of various O serotypes, Streptococcus pneumoniae isolates, strains of Salmonella, Yersinia enterocolitica and Y. pseudotuberculosis and Nocardia sp.

[edit] Proposed epitopes

Arabinomannan portion of the antigen

[edit] Proposed Utility

This antibody might be involved in blocking of mycobacterial invasion. SMITB14 may prevent the uptake of M. tuberculosis through receptor(s) that facilitate bacterial survival and growth.

[edit] Weblink

PubMed Central

[edit] External Links