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- Ticrynafen Tienilic acid was found to act as a suicide substrate at the cytochrome P450 enzymes involved in drug metabolism. Unfortunately, the metabolic rea ...1 KB (204 words) - 09:43, 11 August 2008
- FASTA format >gi|5524211|gb|AAD44166.1| cytochrome b <nowiki>[</nowiki>[[Asian elephant|Elephas maximus maximus]]<nowiki>] ...13 KB (1766 words) - 11:08, 19 August 2008
- Pharmacogenetics ... part of the inborn system for clearing the body of [[xenobiotic]]s, the [[cytochrome P450 oxidase]]s (CYP450) are heavily involved in [[drug metabolism]], and ...7 KB (983 words) - 05:45, 21 August 2008
- Cimetidine Cimetidine is a known inhibitor of many [[isozyme]]s of the [[cytochrome P450]] enzyme system (specifically [[CYP1A2]], [[CYP2C9]], [[CYP2C19]], [[ ...8 KB (1141 words) - 05:03, 25 August 2008
- HB plot ... reductase]] to oxidize their [[substrate]]s. [[CYP2B4]], a member of the [[cytochrome P450]] family is the only protein within this family, whose [[X-Ray struct ... [[Image:P450.jpg|frame|center|HB Plot and structure of Cytochrome P450 2B4 in closed form]]8 KB (1156 words) - 09:51, 17 September 2008
- Adverse drug reaction Inheriting abnormal [[allele]]s of [[cytochrome]] [[cytochrome P450|P450]] can alter drug metabolism. Tables are available to check for d ... =====Cytochrome P450=====10 KB (1362 words) - 09:55, 28 August 2008
- Drug interaction ... olved in metabolic drug interactions is the enzyme system comprising the [[cytochrome P450 oxidase]]s. This system may be affected by either enzyme induction o ...5 KB (686 words) - 10:34, 28 August 2008
- Artemisinin ... nvolves a mevalonate pathway, expression of amorphadiene synthase, a novel cytochrome P450 monooxygenase (CYP71AV1) and its redox partner from A. annua. A three ...14 KB (2074 words) - 05:03, 10 October 2008
- Glutathione ... in the case of ''N''-acetyl-''p''-benzoquinone imine (NAPQI), the reactive cytochrome P450-reactive metabolite formed by paracetamol (or acetaminophen as it is ...6 KB (856 words) - 04:41, 24 October 2008
- Progestrone ... gove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti HCrystal structures of human cytochrome P450 3A4 bound to metyrapone and progesteroneScience v305, p.683-686 Cytochromes P450 (P450s) metabolize a wide range of endogenous compounds and xenobiot ...8 KB (1073 words) - 09:35, 19 February 2009
- Ethinyl Estradiol ... ours later. It undergoes extensive metabolism in the liver involving the [[cytochrome P450]] 3A4 isoenzyme. EE and its metabolites are in excreted with the bile ...12 KB (1540 words) - 09:12, 24 February 2009
- Dehydroepiandrosterone DHEA is produced from cholesterol through two cytochrome P450 enzymes. Cholesterol is converted to pregnenolone by the enzyme P450 ...20 KB (2812 words) - 08:55, 20 February 2009
- Pregnenolone ... avage of the side-chain. The [[enzyme]] performing this task is [[P450 scc|cytochrome P450scc]], located in the [[mitochondria]], and controlled by pituitary tr ...5 KB (687 words) - 09:34, 19 February 2009
- 17-Hydroxyprogesterone It is derived from [[progesterone]] via [[17-hydroxylase]], a [[Cytochrome P450 oxidase|P450c17 enzyme]], or from [[17-hydroxypregnenolone]] via 3β- ...7 KB (940 words) - 07:06, 31 October 2008
- Aldosterone ... nal cortex. Most steroidogenic reactions are catalysed by enzymes of the [[cytochrome]] P450 family. They are located within the mitochondria and require adreno ...17 KB (2332 words) - 11:48, 19 February 2009
- Serotonin ... to give tryptamine, which is then [[Hydroxylation|hydroxylated]] by the [[cytochrome P450 monooxygenase]], [[tryptamine 5-hydroxylase]], yielding serotonin.<re ...38 KB (5178 words) - 12:28, 19 February 2009
- 17-alpha-Hydroxyprogesterone It is derived from [[progesterone]] via [[17-hydroxylase]], a [[Cytochrome P450 oxidase|P450c17 enzyme]], or from [[17-hydroxypregnenolone]] via 3β- ...6 KB (817 words) - 10:07, 19 February 2009
- 17-Hydroxypregnenolone ... This step is performed by the [[mitochondria]]l [[cytochrome P450 oxidase|cytochrome P450 enzyme]] 17α-hydroxylase ([[CYP17A1]]) that is present in the [[adr ...5 KB (643 words) - 11:24, 19 February 2009
- Codeine ... version of codeine to morphine occurs in the liver and is catalysed by the cytochrome P450 enzyme CYP2D6. CYP3A4 produces norcodeine and UGT2B7 conjugates codei ...23 KB (3399 words) - 04:10, 29 April 2009
- Buprenorphine ... . Buprenorphine is metabolised by the liver, via the CYP3A4 isozyme of the cytochrome P450 enzyme system, into norbuprenorphine (by N-dealkylation) and other me ...14 KB (2048 words) - 09:16, 30 April 2009
