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- Drug Discovery ... ) trigger the degradation of homologous messenger RNA (mRNA). The specific dsRNAs are processed into small interfering RNA (siRNA), which initiates the cle ... * Introduction of either dsRNA or siRNA into cells leads to inhibition of the biological function encoded ...23 KB (3467 words) - 03:48, 1 September 2008
- RNAi therapeutics ... nts are known as small interfering RNA (siRNA) when they are produced from dsRNA and microRNA (miRNA) when they are produced endogenously as hairpin loop s ... (2) Highly specific and potent to destroy targets: small dsRNA of 22nt long, siRNAs, of complementary sequence of target can be used to d ...3 KB (501 words) - 09:20, 11 August 2008
- RNA ... RNA with two complementary strands, similar to the DNA found in all cells. dsRNA forms the genetic material of some [[virus]]es ([[double-stranded RNA viru ...31 KB (4467 words) - 07:24, 20 August 2008
- Ampligen ... e mid-[[1970]]s, [[Johns Hopkins University]] researchers redesigned the [[dsRNA]] molecule to overcome the toxicities of the Merck compound. By adding a s ... ... ell activities, and also sets in motion certain biological pathways, where dsRNA serves as the catalyst. [http://tobaccodocuments.org/pm/2024986987-7026.ht ...20 KB (2874 words) - 11:26, 22 August 2008
- Datasets in Bioinformatics ... a/cdpred/ Dicer] an RNase III enzyme cleaves pre-miRNA and dsRNA into sort dsRNA (~21 nucleotide) with 2 nucleotide overhang at 3'site.Thus identification ...16 KB (2424 words) - 11:41, 5 September 2008
- RNAi ... bel Prize for physiology. They received the prize for their discovery that dsRNA triggers suppression of gene activity in a homology dependent manner. Its ... * Silencing was triggered efficiently by injected dsRNA, but weakly or not at all by sense or antisense ssRNA.21 KB (3143 words) - 10:35, 9 September 2008