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  • Targeted Drug Delivery
    superior to molecular manipulations aimed at refining the receptor substrate interactions.
    4 KB (602 words) - 13:27, 5 November 2011
  • Drug Discovery
    ... ication of new compounds showing some activity against a target biological receptor, and the progressive optimization of these leads to yield a compound with ... o Receptors
    23 KB (3467 words) - 03:48, 1 September 2008
  • Virtual screening
    ... hence, can usefully exploit different types of information describing the receptor. ... strategy requires a 3-D database of ligands, a 3-D structure of the target receptor (either derived experimentally or from a model built by homology to relate ...
    5 KB (724 words) - 06:29, 11 August 2008
  • Pharmacophore
    ... res in a ligand that are directly related to the ligand's recognition at a receptor site and its biological activity. The structural features are usually desc ... ... roups with similar properties, in order to identify novel ligands. Ligands receptor interactions are typically “polar positive”, “polar negative” or ...
    1 KB (183 words) - 05:28, 1 September 2008
  • Docking
    ... f low energy conformation after binding of [[ligand]] molecule with target/receptor.The compound that bind strongly in the active site of target molecule and ... example drug and enzyme or protein receptor, fit together. Molecular Docking is frequently used to predict the binding ...
    4 KB (593 words) - 04:42, 17 September 2008
  • Molecular Mechanics
    ... . Kollman, "Computational alanine scanning of the 1:1 human growth hormone-receptor complex," J Comput Chem 23, 15-27 (2002).]</ref> <ref name="Mobley">[http: ...
    8 KB (1146 words) - 08:33, 26 August 2008
  • Drug dose
    ... unt of a drug, temperature, intensity of radiation) to the response of the receptor (e.g. organism under study). The response is usually death (mortality), bu ...
    8 KB (1322 words) - 08:32, 11 August 2008
  • 3D Pharmacophore
    ... e active molecules are required. Only molecules which interact at the same receptor site in the same way will share a pharmacophore. Consequently, experiments ...
    2 KB (295 words) - 07:10, 8 September 2008
  • Pharmacology
    ... M., Cay-Rüdiger P. and R. F. Halliwell (2002), The emergence of the drug receptor theory. ''Nature Reviews Drug Discovery'' 1, 637-641 </ref> The first phar ... ... ling or [[metabolic pathway]]s by affecting sites directly on cell-surface receptors (which modulate and mediate cellular signaling pathways controlling cellu ...
    12 KB (1662 words) - 11:32, 20 August 2008
  • Immune System
    ... nvader on its own surface, a process called antigen presentation. When the receptor of a helper T cell recognizes the antigen, the T cell is activated. Once a ... ... s also by bacteria. It can also attack cancer cells. The killer T cell has receptors that are used to search each cell that it meets. If a cell is infected, i ...
    6 KB (969 words) - 11:17, 11 August 2008
  • Diethylstilbestrol
    ... omen for two decades, until the (much more expensive) [[selective estrogen receptor modulator]] [[tamoxifen]] was found to have efficacy similar to DES with f ... ... lic epoxidation, and the epoxide product has affinity towards the estrogen receptors.{{Fact|date=April 2007}} In some cases there are sons with only one testi ...
    34 KB (4923 words) - 11:19, 20 February 2009
  • Alpidem (Ananxyl)
    ... α1 subtype (Kd of 0.33nM and 1.67nM respectively), of the benzodiazepine receptor. However the chemical structure of alpidem is not related to that of the b ... * Benzodiazepine (receptor)
    2 KB (227 words) - 07:18, 18 August 2008
  • Drug targets
    ... target. Depending on the nature of the target, this effect is referred as receptor antagonism, enzyme inhibition, or ion channel blockade. ... ation) or be the opposite of the endogenous substance which in the case of receptors is referred to as inverse agonism
    7 KB (1041 words) - 05:38, 17 September 2008
  • Virtual high throughput screening
    ... o bind to a drug target, typically a [[protein]] [[receptor (biochemistry)|receptor]] or [[enzyme]].<ref name="pmid18600572">{{cite journal | author = | titl ... ... t of structurally diverse ligands that binds to a receptor, a model of the receptor can be build based on what binds to it. These are known as [[pharmacophor ...
    4 KB (504 words) - 08:35, 17 September 2008
  • Docking (molecular)
    ... ecular surface]]/ [[complementary surface]] descriptors. In this case, the receptor’s molecular surface is described in terms of its [[solvent-accessible su ... ... a flexible ligand, and several are attempting to model a flexible protein receptor. Each "snapshot" of the pair is referred to as a '''pose'''. There are man ...
    12 KB (1708 words) - 05:48, 17 September 2008
  • Antibody
    ... ds directly as an integral membrane protein, it does not bind to an IgM Fc receptor like IgE does. ... s antibody is unknown but it has been suggested that it acts as an antigen receptor and that it is needed for B cell activation. A very small amount of IgD is ...
    9 KB (1437 words) - 11:39, 18 August 2008
  • Competitive antagonist
    ... lace the agonist from the binding sites, resulting in a lower frequency of receptor activation.
    1 KB (140 words) - 18:40, 17 August 2008
  • QSAR
    ... involve the interactions of a family of molecules with an [[enzyme]] or [[receptor]] binding site, QSAR can also be used to study the interactions between th ...
    6 KB (859 words) - 09:16, 20 August 2008
  • B Cells and T Cells
    ... L chains, VDJ rearranged on H chains. There is start of expression of IgM receptors. ... ent in the body; the B cell proliferates and secretes a free form of those receptors (antibodies) with identical binding sites as the ones on the original cel ...
    15 KB (2456 words) - 10:44, 18 August 2008
  • IMTECH
    ... m for detection of mutation in a steroid receptor gene that impairs normal receptor function, were developed.
    15 KB (2164 words) - 09:50, 19 August 2008

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