PolysacDB Capsular polysaccharide 2423
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:13, 8 April 2010
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Streptococcus Group B
Basic Structure
The structure of type III polysaccharide is as follows : -3-β-D-Galp-(1-->4)-β-D-Glcp-(1-->6)-β-D-GlcNAcp-(1--> along with the fact that the carboxyl of the -D-NeuNAcp was linked to the O-3 of the adjacent D-galactose to form the type-specific site
Proposed functions
The property of invasiveness is related to the anti-phagocytic properties conferred to Group B Streptococcus by its capsular polysaccharide
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab GBS II/4-1OBA9
Antibody type and class
N/A
Assay System
Counterimmunoelectrophoresis, Radioactive binding assay, Ouchterlony double-diffusion, Latex particle agglutination tests
Cross-reactivity
A9 antibody cross-reacted with group B antigen in gel diffusion reactions with extracts of Lancefield group A, B, C, D, F, and G streptococci
Proposed epitopes
Rhamnose is not an immunodominant determinant contrasts with polyclonal rabbit antiserum to this antigen
Proposed Utility
This Mab was a highly sensitive reagent in detecting soluble group B antigen by counterimmunoelectrophoresis. A9 antibody-coated latex particles were compared with a commercially available polyclonal latex agglutination reagent and shown to be equally sensitive and specific in the detection of soluble group B antigen in urine and cerebrospinal fluid from patients with GBS infections
