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- Prodrug ... through the use of [[redox]]-activation, utilise the large quantities of [[reductase]] [[enzyme]] present in the hypoxic cell to convert the drug into its [[cy ... ... site of the therapeutic target and conversion are the same (e.g., HMG Co-A reductase inhibitors).5 KB (640 words) - 06:41, 25 August 2008
- HB plot ... s that use molecular [[oxygen]] and electrons from [[NADPH cytochrome P450 reductase]] to oxidize their [[substrate]]s. [[CYP2B4]], a member of the [[cytochrom ... ... m CYP2B4 to a conformation state, where binding of [[NADPH cytochrome P450 reductase]] occurs.8 KB (1156 words) - 09:51, 17 September 2008
- Diabetes testicular (5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency)77 KB (11136 words) - 04:41, 26 September 2008
- Androgen ... ostate gland, testes, hair follicles, and adrenal glands by the enzyme 5α-reductase by means of reducing the 4,5 double-bond. Dihydrotestosterone belongs to t ...7 KB (1027 words) - 07:00, 17 October 2008
- Glutathione ... form, since the enzyme that reverts it from its oxidized form, glutathione reductase, is constitutively active and inducible upon oxidative stress. In fact, t ... ... in the liver). GSH can be regenerated from GSSG by the enzyme glutathione reductase.6 KB (856 words) - 04:41, 24 October 2008
- Estradiol ... one, followed by conversion of estrone to estradiol by 17β-hydroxysteroid reductase. Smaller amounts of estradiol are also produced by the adrenal cortex, and ...21 KB (2912 words) - 05:26, 24 February 2009
- Melatonin ... ural insights into the interaction of melatonin and analogues with quinone reductase 2Biochem. J. v413, p.81-91 ... ural insights into the interaction of melatonin and analogues with quinone reductase 2Biochem. J. v413, p.81-915 KB (673 words) - 09:16, 19 February 2009
- Progestrone ... on transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase. Structure of the reduced enzyme-progesterone complex and the roles of res ... ... cs, and by determination of crystallographic structures for the Y186F PETN reductase and reduced wild-type enzyme-progesterone complex. Residues His181 and His ...8 KB (1073 words) - 09:35, 19 February 2009
- Testosterone ... g the androgen effects. It is important to note that if there is a 5-alpha reductase deficiency,<!-- in the womb? during childhood? --> the body (of a human) w ...35 KB (5048 words) - 06:11, 4 March 2009
- Dihydrotestosterone ... licle]]s, and [[adrenal gland]]s by the [[enzyme]] [[5-alpha reductase|5α-reductase]] by means of reducing the 4,5 double-bond. Dihydrotestosterone belongs to ... ... he drugs belonging to the group known as [[5-alpha-reductase inhibitor|5α-reductase inhibitors]] are used for treatment of problems stemming from DHT. This gr ...10 KB (1484 words) - 12:19, 19 February 2009
- 5beta-Cholestanone ... oxidation product of coprosterol. It is a substrate of cholestenone 5beta-reductase [EC 1.3.1.3] (KEGG).1 KB (185 words) - 04:12, 11 December 2009
- Tetrahydrodeoxycorticosterone ... in from [[deoxycorticosterone]] by the action of two enzymes, [[SRD5A1|5α-reductase type I]] and 3α-hydroxysteroid dehydrogenase.<ref>Agís-Balboa RC, Pinna ...4 KB (506 words) - 12:40, 19 February 2009
- Finasteride An orally active TESTOSTERONE 5-ALPHA-REDUCTASE inhibitor. It is used as a surgical alternative for treatment of benign ...1 KB (232 words) - 04:48, 11 December 2009
- 7-a,25-Dihydroxycholesterol ... ed metabolites of 27-hydroxycholesterol suppressed the activity of HMG-CoA reductase also in 90VA-VI cells. (PMID: 9059514)2 KB (324 words) - 05:33, 11 December 2009
- Cholesterol ... esterol is primarily synthesized from [[acetyl CoA]] through the [[HMG-CoA reductase pathway]] in many [[cell (biology)|cells]] and [[biological tissue|tissues ... ... The former scavenges circulating LDL from the bloodstream, whereas HMG-CoA reductase leads to an increase of endogenous production of cholesterol.<ref>{{cite j ...33 KB (4573 words) - 06:28, 20 February 2009
- D-Isoboldine Isoboldine was determined to inhibit rabit lens aldose reductase(IC50 2.7X10-4M).3 KB (431 words) - 04:05, 11 December 2009
- BIAdb BERBERINE SULFATE 1494 Aldose reductase inhibitor2 KB (250 words) - 07:03, 10 December 2009
- BIAdb Berberine iodide 1493 Aldose reductase inhibitor2 KB (240 words) - 09:08, 10 December 2009
- BIAdb Higenamine-1-carboxylic acid 2273 Dihydropteridine reductase inhibitor2 KB (240 words) - 11:13, 14 December 2009
- Protein disulfide-isomerase precursor341) ... d rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefo ...2 KB (203 words) - 08:52, 15 December 2009
